Lives listing by nationality: English
- Selwyn, George Augustus (born 1719–died 1791), English wit, politician
- Sergeant, John (born 1623–died before 1707), English churchman, Catholic, religious controversialist
- Serjeant, Cornelius (flourished 1692–1698), English [unknown occupation]
- Seward, Anna (born 1742–died 1809), English author, poet
- Seymour, Charles, 6th duke of Somerset (born 1662–died 1748), English aristocrat, courtier
- Seymour, Sir Edward (born 1633–died 1708), English politician, member of Parliament
- Seymour, Frances, duchess of Somerset [née Thynne] (born 1699–died 1754), English aristocrat, poet
- Seymour Conway, Francis, 1st marquess of Hertford (born 1718–died 1794), English aristocrat, courtier, politician, government minister
- Seymour Conway, Field Marshall Henry (born 1721–died 1795), English soldier, army officer, government minister
- Sharp, Abraham (born 1653–died 1742), English mathematician, scientific-instrument maker
- Sharp, Anne (born c. 1777–died after 1851), English governess, tutor, author, playwright
- Sharp, Granville (born 1735–died 1813), English abolitionist
- Sharp, Richard (born 1759–died 1835), English politician, member of Parliament, wit, academician
- Sharpe, Horatio (born 1718–died 1790), English civil servant, colonial governor
- Sharpe, Joshua (born c. 1718–died 1786), English lawyer
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