Lives listing by nationality: English
- Scott, John (born 1730–died 1783), English author, poet
- Scott, John, 1st earl of Eldon (born 1751–died 1838), English lawyer, politician, member of Parliament
- Scott, Sarah [née Robinson] (born 1723–died 1795), English author, novelist
- Scott, Sir William, Baron Stowell (born 1745–died 1836), English academic, lawyer, judge, politician, member of Parliament
- Scriblerus Club (founded 1713), English literary club
- Scudamore, John, 1st Viscount Scudamore (born 1601–died 1671), English courtier, politician, member of Parliament, army officer, royalist
- Scudamore, Sophia [née Westcomb] (born after 1722), English home-maker
- Scurlock, Elizabeth [née Still] (died 1713), English home-maker
- S. E. (flourished c. 1735), English [unknown occupation]
- Seaman, Reverend William (born 1607–died 1680), English churchman, Orientalist, translator
- Seamer, James (born c. 1657–died 1739), English goldsmith, businessman, jeweller, banker, author
- Secker, Reverend Thomas, archbishop of Canterbury (born 1693–died 1768), English churchman
- Sedgwick, Reverend Adam (born 1785–died 1873), English geologist, university teacher, academician
- Sedgwick, Edward (flourished 1764), English lawyer, civil servant
- Seele, George (born c. 1728–died 1810), English schoolteacher, churchman
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