Lives listing with initial: S
- Spain, Cortes of (founded c. 1230), Spanish political body
- Spalding, Reverend John (born c. 1631–died 1699), Scottish churchman
- Spallanzani, Lazzaro (born 1729–died 1799), Italian biologist, scientist
- Spanheim, Ezechiel von, Freiherr von Spanheim (born 1629–died 1710), Swiss diplomat, scholar, classicist, numismatist
- Spannut, Willem (born c. 1631), French physician
- Spedding, James (born 1808–died 1881), English author, biographer, literary editor
- Speedy, George (flourished c. 1774), Scottish weaver
- Spence, Joseph (born 1699–died 1768), English churchman, poet
- Spence, Keith (died c. 1809), Scottish [unknown occupation]
- Spence, Mirabella [née Collier] (born 1670–died 1755), English home-maker
- Spencer, Charles, 3rd earl of Sunderland (born 1675–died 1722), English aristocrat, politician
- Spencer, Charles, 3rd duke of Marlborough (born 1706–died 1758), English aristocrat, politician, army officer
- Spencer, George John, 2nd Earl Spencer (born 1758–died 1834), English politician, bibliophile, collector, academician
- Spencer, John (born 1630–died 1693), English churchman, university teacher, university administrator
- Spencer, John, 1st Earl Spencer (born 1734–died 1783), English aristocrat, patron, collector, politician, member of Parliament
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