Lives listing with initial: S
- Sourgel, Mme — de (flourished 1739–1740), [unknown nationality] home-maker
- Sousa Coutinho, Domingos António de, 1st marquis of Funchal (born 1760–died 1833), Portuguese aristocrat, diplomat, politician, colonial governor
- South, Sir James (born 1785–died 1867), English astronomer, scientist
- South, Robert (born 1634–died 1716), English churchman, theologian
- Southampton County, Virginia, Committee of Safety of (active 1776), American civic body
- South Carolina, Grand Council / His Majesty’s Council of [upper house of the South Carolina Assembly] (active 1758), American legislative body
- South Carolina, Inhabitants of (appears in EE from c. 1670), American colonists
- Southgate, Robert (born 1741–died 1833), American [unknown occupation]
- Southwell, Edward (born 1671–died 1730), English civil servant, government minister, politician, member of Parliament
- Southwell, Robert (born 1608–died 1677), Irish landowner, civil servant
- Southwell, Sir Robert (born 1635–died 1702), Irish diplomat, civil servant, academician, politician, member of Parliament
- Southworth, Constant (born 1730–died 1813), American politician
- Sowter, John (flourished c. 1704), English [unknown occupation]
- Spademan, Reverend John (died 1708), English churchman, Nonconformist, schoolteacher
- Spaen, Elisabeth Agnès Jacoba von, baroness von Spaen [née de Nassau La Lecq] (born 1724–died 1798), Dutch aristocrat
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