Lives listing with initial: S
- Smith, John R. (flourished 1850–1900), American merchant, mill-owner
- Smith, John Thomas (born 1766–died 1833), English painter, draughtsman, engraver, antiquarian, archivist, author
- Smith, Margaret [née Douglas] (born 1694–died 1784), Scottish home-maker
- Smith, Nathaniel (flourished 1789), American civil servant, army officer
- Smith, P. (flourished 1686–1687), American [unknown occupation]
- Smith, Lady R. C. (flourished 1790–1820), [unknown nationality] aristocrat
- Smith, Doctor Ralph (flourished 1686–1689), English physician, merchant
- Smith, Richard (flourished 1759–1761), American trader, guide, government agent, interpreter
- Smith, Robert (born 1689–died 1768), English mathematician, academician, editor, literary executor
- Smith, Robert (born 1752–died 1838), English banker, politician
- Smith, Samuel (born c. 1732–died 1808), English schoolteacher
- Smith, Samuel Stanhope (born 1751–died 1819), American churchman, university administrator
- Smith, Stanley M. (flourished 1879–1939), American soldier
- Smith, Sydney (born 1771–died 1845), English author, wit
- Smith, Thomas (born 1638–died 1710), English Orientalist, biographer, author
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