Lives listing with initial: S
- Smith, Benjamin (flourished 1789), American private secretary
- Smith, Caroline [née Vernon] (born 1761–died 1833), English home-maker
- Smith, Lieutenant Charles (flourished 1758), American army officer
- Smith, Charles Britiffe (born c. 1797–died c. 1870), English collector
- Smith, Charles Hamilton (born 1776–died 1859), English biologist, soldier, academician, army officer, author, translator
- Smith, Charlotte [née Turner] (born 1749–died 1806), English author, novelist, poet
- Smith, Charlotte [née Izard] (born 1770–died 1792), American home-maker
- Smith, Christopher (flourished 1758), [unknown nationality & occupation]
- Smith, Ezekiel (flourished 1661), English author, medical author
- Smith, Frederick (born 1757–died 1823), English religious pamphleteer
- Smith, George W. (born 1762–died 1811), American [unknown occupation]
- Smith, Reverend Humfry (born 1655–died 1709), English churchman
- Smith, James (born 1719–died 1806), Irish merchant, lawyer, politician
- Smith, Doctor John (born 1630–died 1679), English physician, medical author, author
- Smith, John (born 1655/1656–died 1723), English politician, civil servant
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