Lives listing by occupation: politician
- Deluc, Jacques François (born 1698–died 1780), Swiss clockmaker, politician, tradesman
- Démeunier, Jean Nicolas (born 1741–died 1814), French politician, revolutionary, essayist, political historian
- Dempster, George (born 1732–died 1818), Scottish lawyer, agriculturalist, East India Company official, politician, member of Parliament
- Denham, Sir John (born 1614/1615–died 1669), Irish poet, courtier, politician, member of Parliament, royalist
- Denison, William Joseph (born 1770–died 1849), English politician, member of Parliament
- Desaussure, Daniel (born 1736–died 1798), American merchant, politician
- Desgouttes, Henri Zacharie (born 1762–died 1834), Swiss politician, revolutionary, author
- Deslandes, Paul, Baron Deslandes-Preuilly (born 1746–died 1830), French administrator, politician
- Dickinson, John (born 1732–died 1808), American lawyer, plantation-owner, pamphleteer, essayist, politician
- Didier, Jean Emmanuel (born c. 1760–died 1829), Swiss bookseller, printer, politician
- Digby, Edward (born c. 1693–died 1746), English politician, member of Parliament
- Digby, Henry, 1st Earl Digby (born 1731–died 1793), English aristocrat, politician, member of Parliament, civil servant
- Digby, Robert (born after 1687–died 1726), English politician, member of Parliament
- Digby, William, 5th Baron Digby (born 1661–died 1752), English politician, philanthropist
- Digges, Dudley (born 1729–died 1790), American politician
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