Lives listing by occupation: member of Parliament
- Smyth, Boyle (died 1662), Irish gentleman, politician, member of Parliament
- Somers, John, 1st Baron Somers (born 1651–died 1716), English lawyer, politician, member of Parliament, civil servant, academician
- Somerville, Sir James, baronet (born c. 1698–died 1748), Irish gentleman, politician, member of Parliament
- Southwell, Edward (born 1671–died 1730), English civil servant, government minister, politician, member of Parliament
- Southwell, Sir Robert (born 1635–died 1702), Irish diplomat, civil servant, academician, politician, member of Parliament
- Spencer, John, 1st Earl Spencer (born 1734–died 1783), English aristocrat, patron, collector, politician, member of Parliament
- Spencer, John Charles, 3rd Earl Spencer (born 1782–died 1845), English politician, member of Parliament, sportsman, agriculturalist
- Stanhope, James, 1st Earl Stanhope (born 1673–died 1721), English army officer, diplomat, politician, member of Parliament
- Stanhope, Lovell (born 1720–died 1783), English lawyer, politician, member of Parliament
- Stanhope, William, 1st earl of Harrington (born 1683–died 1756), English diplomat, politician, member of Parliament
- Stanhope, Sir William (born 1702–died 1772), English politician, member of Parliament, wit
- Stanley, Hans (born 1721–died 1780), English politician, member of Parliament
- Stannard, Eaton (born 1685–died 1755), Irish lawyer, politician, member of Parliament
- Stanwix, Lieutenant-general John (born c. 1690–died 1766), English army officer, politician, member of Parliament
- Stewart, Robert, Viscount Castlereagh (born 1769–died 1822), Irish politician, member of Parliament
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