Lives listing by nationality: English
- South, Robert (born 1634–died 1716), English churchman, theologian
- Southwell, Edward (born 1671–died 1730), English civil servant, government minister, politician, member of Parliament
- Sowter, John (flourished c. 1704), English [unknown occupation]
- Spademan, Reverend John (died 1708), English churchman, Nonconformist, schoolteacher
- Spedding, James (born 1808–died 1881), English author, biographer, literary editor
- Spence, Joseph (born 1699–died 1768), English churchman, poet
- Spence, Mirabella [née Collier] (born 1670–died 1755), English home-maker
- Spencer, Charles, 3rd earl of Sunderland (born 1675–died 1722), English aristocrat, politician
- Spencer, Charles, 3rd duke of Marlborough (born 1706–died 1758), English aristocrat, politician, army officer
- Spencer, George John, 2nd Earl Spencer (born 1758–died 1834), English politician, bibliophile, collector, academician
- Spencer, John (born 1630–died 1693), English churchman, university teacher, university administrator
- Spencer, John, 1st Earl Spencer (born 1734–died 1783), English aristocrat, patron, collector, politician, member of Parliament
- Spencer, John Charles, 3rd Earl Spencer (born 1782–died 1845), English politician, member of Parliament, sportsman, agriculturalist
- Spencer, Nicholas (died 1689), English merchant, politician, civil servant, governor
- Spink, John (born 1729–died 1794), English draper, banker, accountant, philanthropist
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