Lives listing by nationality: English
- Society for the Encouragement of Arts, Manufactures and Commerce (founded 1754), English academy, learned society
- Society for the Propagation of the Gospel (founded 1701), English missionary organization
- Socket, Mrs — (flourished c. 1792), English home-maker
- Somers, John, 1st Baron Somers (born 1651–died 1716), English lawyer, politician, member of Parliament, civil servant, academician
- Princess Sophia Matilda, of Gloucester (born 1773–died 1844), English aristocrat
- South, Sir James (born 1785–died 1867), English astronomer, scientist
- South, Robert (born 1634–died 1716), English churchman, theologian
- Southwell, Edward (born 1671–died 1730), English civil servant, government minister, politician, member of Parliament
- Sowter, John (flourished c. 1704), English [unknown occupation]
- Spademan, Reverend John (died 1708), English churchman, Nonconformist, schoolteacher
- Spedding, James (born 1808–died 1881), English author, biographer, literary editor
- Spence, Joseph (born 1699–died 1768), English churchman, poet
- Spence, Mirabella [née Collier] (born 1670–died 1755), English home-maker
- Spencer, Charles, 3rd earl of Sunderland (born 1675–died 1722), English aristocrat, politician
- Spencer, Charles, 3rd duke of Marlborough (born 1706–died 1758), English aristocrat, politician, army officer
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