Lives listing by nationality: English
- Skinner, Stephen (born 1623–died 1667), English linguist, lexicographer
- S. L. (flourished c. 1659), English amanuensis
- Slade of Deptford, William (flourished c. 1757), English [unknown occupation]
- Sleigh, William (died 1799), English lawyer
- Small, Mr — (flourished c. 1784), English lawyer
- Smalling, William (died 1786), English slaveholder, plantation-owner, attorney
- Smalridge, Reverend George, bishop of Bristol (born 1662–died 1719), English churchman
- Smart, Christopher (born 1722–died 1771), English author, poet, madman
- Smith, Ann (flourished 1759), English printer
- Smith, Anthony (flourished 1660–1668), English surgeon
- Smith, Caroline [née Vernon] (born 1761–died 1833), English home-maker
- Smith, Charles Britiffe (born c. 1797–died c. 1870), English collector
- Smith, Charles Hamilton (born 1776–died 1859), English biologist, soldier, academician, army officer, author, translator
- Smith, Charlotte [née Turner] (born 1749–died 1806), English author, novelist, poet
- Smith, Ezekiel (flourished 1661), English author, medical author
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