Lives listing by nationality: English
- Shute Barrington, John, 1st Viscount Barrington (born 1678–died 1734), English politician, speculator, author
- Sibbald, Sir James (died 1819), English East India Company official, merchant
- Siddons, William (born 1744–died 1808), English actor
- Sidney, Algernon (born 1622–died 1683), English [unknown occupation]
- Simcoe, John Graves (born 1752–died 1806), English army officer, colonial administrator, politician, member of Parliament
- Simpson, Doctor William (died 1680), English physician, alchemist
- Skeffington, John, 2nd Viscount Massereene (born 1632–died 1695), English politician, member of Parliament, aristocrat
- Skinner, Stephen (born 1623–died 1667), English linguist, lexicographer
- S. L. (flourished c. 1659), English amanuensis
- Slade of Deptford, William (flourished c. 1757), English [unknown occupation]
- Sleigh, William (died 1799), English lawyer
- Small, Mr — (flourished c. 1784), English lawyer
- Smalridge, Reverend George, bishop of Bristol (born 1662–died 1719), English churchman
- Smart, Christopher (born 1722–died 1771), English author, poet, madman
- Smith, Ann (flourished 1759), English printer
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