Lives listing by nationality: English
- Orde, Thomas (born 1746–died 1807), English politician, member of Parliament
- Ordnance, officers of the (appears in EE c. 1717), English government official
- Osbaldeston, Reverend Richard, bishop of London (born 1691–died 1764), English churchman, bishop
- Osborn, Mr — (flourished 1750–1775), English [unknown occupation]
- Osborne, Francis, 5th duke of Leeds (born 1751–died 1799), English aristocrat, government minister, politician, member of Parliament
- Osborne, Mary Godolphin, duchess of Leeds [née Godolphin] (born 1723–died 1764), English aristocrat
- Osborne, Peregrine, 2nd duke of Leeds (born 1659–died 1729), English naval officer
- Osborne, Thomas, 1st duke of Leeds (born 1632–died 1712), English politician, member of Parliament
- Otway, Thomas (born 1652–died 1685), English author, playwright, poet
- Oughton, Sir James Adolphus Dickenson (born 1719–died 1780), English army officer, antiquarian
- Owen, Edward (died 1706), English hatter, politician, tradesman
- Owen, John (died 1679), English stationer, tradesman
- Owen, Margaret (born 1742–died 1816), English home-maker
- Owen, Reverend William (born c. 1618–died 1672), English churchman
- Owen’s Weekly Chronicle & Westminster Journal (founded 1758), English newspaper
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