Lives listing by nationality: American
- Smith, William (born 1728–died 1814), American merchant, politician
- Smith, Major William (born 1751–died 1837), American colonist, plantation-owner, army officer, politician
- Smith, William (born 1755–died 1816), American merchant
- Smith, Lieutenant-colonel William Stephens (born 1755–died 1816), American revolutionary army officer, politician, civil servant
- Snyder, Simon (born 1759–died 1819), American politician
- Southampton County, Virginia, Committee of Safety of (active 1776), American civic body
- South Carolina, Grand Council / His Majesty’s Council of [upper house of the South Carolina Assembly] (active 1758), American legislative body
- South Carolina, Inhabitants of (appears in EE from c. 1670), American colonists
- Southgate, Robert (born 1741–died 1833), American [unknown occupation]
- Southworth, Constant (born 1730–died 1813), American politician
- Spierin, Reverend George W. (flourished c. 1797), American churchman
- Spooner, Ephraim (born 1735–died 1818), American [unknown occupation]
- Spotsylvania County, a friend in (flourished 1789), American [unknown occupation]
- Spring, Seth (flourished 1789), American soldier, landowner
- Stafford County, Virginia, Court of (active 1691), American legal institution
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