Lives listing by nationality: American
- Ellsworth, Oliver (born 1745–died 1807), American judge, politician
- Elmer, Jonathan (born 1745–died 1817), American physician, judge, politician
- Elsworth, Dorothy and Vandine (appears in EE c. 1789–c. 1790), American [unknown occupation]
- Emery, Samuel (born 1751), American merchant
- Emmons, Reverend Doctor Nathaneal (born 1769–died 1840), American churchman, Congregationalist
- Emory, Charles (born c. 1750–died 1811), American colonist, plantation-owner, politician, civil servant, surveyor
- Ernest, Matthew (died c. 1805), American [unknown occupation]
- Essex County, Virginia, citizens of (appears in EE 1793), American civic body
- The Essex Journal (founded 1773), American newspaper
- Eustace, John (flourished 1767–1768), American physician
- Evance, Sir Stephen (born 1654/1655–died 1712), American goldsmith, financier, politician, member of Parliament
- Evans, Oliver (born 1755–died 1819), American millwright, inventor, tradesman
- Eveleigh, Nicholas (born c. 1748–died 1791), American colonist, plantation-owner, civil servant
- Ewing, Maskell (born 1721–died 1796), American farmer, police-officer, judge
- Fairfax County, Virginia, vestry of Truro parish in (active 1766), American parish body
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