Lives listing with initial: S
- Skene, David (born 1731–died 1770), Scottish naturalist, physician, midwife, academician
- Skene, George (born 1740–died 1803), Scottish philosopher, historian
- Skene, Robert (born 1719–died 1787), Scottish army officer, soldier, politician, member of Parliament
- Skillerin, George (flourished 1770), [unknown nationality & occupation]
- Skinker, John (flourished 1785), [unknown nationality & occupation]
- Skinner, Stephen (born 1623–died 1667), English linguist, lexicographer
- S. L. (flourished c. 1659), English amanuensis
- Slade of Deptford, William (flourished c. 1757), English [unknown occupation]
- Sladus, Mattheus (born 1628–died 1689), Dutch physician
- Sleigh, William (died 1799), English lawyer
- Sloane, Sir Hans (born 1660–died 1753), Irish physician, collector, academician
- Slocum, Holder (born 1748–died 1827), American [unknown occupation]
- Sluse, René François de (born 1622–died 1685), Belgian churchman, mathematician, academician
- Small, Mr — (flourished c. 1784), English lawyer
- Smallwood, William (born 1732–died 1792), American [unknown occupation]
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