Lives listing by occupation: merchant
- Desaussure, Daniel (born 1736–died 1798), American merchant, politician
- Dinwiddie, Robert (born 1692–died 1770), Scottish merchant, colonial administrator
- Domenico, Gaetano Drago di (flourished 1789), Italian merchant
- Donald, Alexander (flourished 1787–1798), Scottish merchant
- Drake, Mr — (flourished c. 1766), English merchant
- Drinker, Henry (born 1734–died 1809), American Quaker, merchant, speculator, politician
- Duguid, John (flourished 1766–1789), Scottish merchant
- Dummer, Thomas (flourished c. 1701), English sea captain, merchant, ship-owner
- Duncan, Jonathan (born 1756–died 1811), Scottish merchant, East India Company official, colonial governor
- Duval, David (born 1711–died 1791), Swiss merchant
- East India Company, The Honourable the Court of Proprietors of the (founded 1600–disbanded 1874), British merchant
- Eaton, William (flourished c. 1786), English merchant, author
- Edwards, John (born 1730–died 1773), English merchant, actuary
- Eliot, Samuel (born 1739–died 1820), American merchant, banker, philanthropist
- Ellery, William (born 1727–died 1820), American merchant, politician
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