Lives listing by nationality: Irish
- Sheridan, Richard Brinsley (born 1751–died 1816), Irish author, playwright, politician
- Sheridan, Reverend Doctor Thomas (born 1687–died 1738), Irish schoolteacher, churchman
- Sheridan, Thomas (born c. 1719–died 1788), Irish actor, orthoepist
- Shiell, John (flourished c. 1735), Irish wine-merchant, tradesman
- Sican, Mrs — (flourished c. 1735), Irish author, poet
- Sican, John (died 1735), Irish physician
- Sloane, Sir Hans (born 1660–died 1753), Irish physician, collector, academician
- Smedley, Jonathan (born 1671–died 1729), Irish churchman, author
- Smith, James (born 1719–died 1806), Irish merchant, lawyer, politician
- Smith-Stanley, Elizabeth, countess of Derby [née Farren] (born c. 1759–died 1829), Irish actress, aristocrat
- Smyth, Boyle (died 1662), Irish gentleman, politician, member of Parliament
- Smyth, Captain John (died 1688), Irish steward, estate manager
- Smyth, Thomas (born 1737–died 1824), Irish merchant, banker
- Sneyd, Mary (flourished 1795–1838), Irish gentlewoman
- Somerville, Sir James, baronet (born c. 1698–died 1748), Irish gentleman, politician, member of Parliament
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