Lives listing by nationality: English
- Sackville, Charles, earl of Dorset and Middlesex (born 1643–died 1706), English aristocrat, poet, author
- Sackville, John Frederick, 3rd duke of Dorset (born 1745–died 1799), English courtier, cricketer, politician, member of Parliament
- Sackville, Lionel Cranfield, 1st duke of Dorset (born 1688–died 1765), English government minister
- Sadler, John (born 1615–died 1674), English author, political theorist, reformer, university administrator
- Sadler, John (flourished 1677–1678), English alchemist
- Sadler, Jonathan (flourished 1797–1799), English painter
- Sainsbury, John (born c. 1793–died 1869), English bookseller, author
- Saint Amand, James (born 1687–died 1754), English scholar, classicist, bibliophile, collector
- The Saint James’s Chronicle (founded 1761), English newspaper
- Saint Paul, Horace (born 1729–died 1812), English soldier of fortune, army officer, diplomat
- Saint Quintin, Sir William, 3rd baronet (born 1662–died 1723), English politician, member of Parliament, civil servant
- Salisbury, William (died 1823/1829), English nurseryman, botanist, horticulturist
- Salmon, Thomas (born 1679–died 1767), English author, historian, travel-writer
- Salusbury, Harriet Maria [née Pemberton] (born 1794–died 1841), English home-maker
- Salusbury, Lady Sarah Burroughs [née King] (born 1721–died 1804), English home-maker
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