Lives listing by nationality: American
- Reynolds, William (died 1802), American merchant, tax-official
- Rhinelander, William [junior] (born 1753–died 1825), American sugar refiner, landowner, businessman, trader
- Rice, James (flourished 1789), American politician
- Rice, John (born c. 1753–died 1803), American [unknown occupation]
- Rice, Thomas (born 1734–died 1812), American physician, politician
- Richards, John (flourished 1766), American [unknown occupation]
- Richardson, Archibald (born 1756–died 1804), American [unknown occupation]
- Richmond, Christopher (died c. 1795), American [unknown occupation]
- Riggs, Caleb (born c. 1758–died 1826), American [unknown occupation]
- Ripley, Ezra (born 1751–died 1841), American churchman, Congregationalist
- Rittenhouse, David (born 1732–died 1796), American scientist, inventor, civil servant, industrialist
- Roane, Christopher (born 1756–died 1828), American [unknown occupation]
- Robertson, James (born 1742–died 1814), American [unknown occupation]
- Robinson, Beverley (born 1723–died 1792), American landowner, politician, civil servant
- Robinson, John (born 1704–died 1766), American politician, civil servant
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